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Approved Use

Repatha® is an injectable prescription medicine used:

  • in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of heart surgery. READ MORE
  • along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia [HeFH]) to reduce low-density lipoprotein (LDL) or bad cholesterol.
For adults with heart disease
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What Is Bad Cholesterol (LDL-C)?

LDL cholesterol is often called “bad cholesterol.”

This is because it can build up in the walls of your arteries and form plaque. Plaque rupture may cause clogs, putting you at risk of a serious cardiovascular event, like a heart attack or stroke.

Normal Artery

Clear blood flow

Cholesterol Building in Artery

Plaque blocks blood flow

Plaque Building in Artery Wall
1
Low-density lipoprotein (LDL) cholesterol is considered “bad” because it can deliver cholesterol into artery walls, forming fatty deposits known as plaque.
2
Plaque rupture can create clogs and make it difficult for blood to flow through your body.
3
Sometimes the clogs can completely block blood flow, leading to a devastating heart attack or stroke—which is why high LDL-C must be lowered.
High LDL Icon
Why Is My Bad Cholesterol High?

There are many reasons why someone’s bad cholesterol levels would be high. Inactivity and an unhealthy diet can contribute to harmful levels. Other factors such as your genetic makeup or family history may make it more difficult for your body to remove or break down bad cholesterol.

Stethoscope Icon
How Do I Lower My Bad Cholesterol?

Diet improvements and increased exercise can help lower bad cholesterol, but sometimes you need to do more.

That’s why it’s important to talk to your doctor about lifestyle changes and cholesterol-lowering medicines to lower bad cholesterol and reduce risk of another devastating heart attack or stroke.

Repatha® (evolocumab) Doctor Discussion Guide Download
Talk to Your Doctor About High LDL-C
Not seeing enough change in your LDL levels? Talk to your doctor to see if Repatha® is right for you. We know it can sometimes be difficult to have a conversation about your health with your doctor, so here’s a Discussion Guide with talking points you can consider using.
DOWNLOAD GUIDE
  • Want to learn more?

    Check out some cardiovascular disease organizations dedicated to patient education, advocacy, and more.

    American Heart Association® Logo
    American Heart Association
    American Heart Association
    The American Heart Association (AHA) is dedicated to fighting heart disease and stroke. Their mission is to improve the lives of all Americans by providing public health education in a variety of ways. Check out their website for heart disease education and support, and tips for healthy living, like their “Life’s Simple 7”—7 small steps to big changes to better living.
    CardioSmart® American College of Cardiology® Logo
    CardioSmart American College of Cardiology Foundation
    CardioSmart American College of Cardiology Foundation
    CardioSmart is the patient education and empowerment initiative brought to you by the American College of Cardiology. Their mission is to help patients treat, and manage their cardiovascular disease.
    Family Heart Foundation® Logo
    Family Heart Foundation
    Family Heart Foundation
    The Family Heart Foundation focuses on timely identification and improved care of familial hypercholesterolemia (FH). Through research, advocacy, and education, they drive change and empower families to navigate their own health.
    Family Heart Foundation
    The FH Foundation
    The FH Foundation is a patient-centered nonprofit organization dedicated to research, advocacy, and education of Familial Hypercholesterolemia (FH). Their mission is to raise awareness and save lives by increasing the rate of early diagnosis and encouraging proactive treatment.
    Mended Hearts® Logo
    Mended Hearts
    Mended Hearts
    Mended Hearts is a national and community-based nonprofit organization that has been offering the gift of hope to heart disease patients, their families, and caregivers. Mended Hearts provides a variety of programs, including, local support, available over the phone or in person.
    WomenHeart® Foundation Logo
    WomenHeart Foundation
    WomenHeart Foundation
    WomenHeart is a national coalition for women with heart disease with a focus on early detection, accurate diagnosis, and proper treatment. WomenHeart’s mission is to improve the health and quality of life of women living with or at risk of heart disease, and to advocate for their benefit.

These third party websites may contain helpful resources and are provided for your information only. Amgen does not endorse and is not responsible for the content included in these websites or any associated resources.

Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-dose prefilled syringes and the inside of the needle caps on the single-dose prefilled SureClick® autoinjectors contain dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?

Repatha® can cause serious side effects including serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes) and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

APPROVED USE

What is Repatha®?

Repatha® is an injectable prescription medicine used:

  • in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of heart surgery.
  • along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia [HeFH]) to reduce low density lipoprotein (LDL) or bad cholesterol.

Please see full Prescribing Information.

Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including
if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-dose prefilled syringes and the inside of the needle caps on the single-dose prefilled SureClick® autoinjectors contain dry natural rubber. The single-dose Pushtronex®