Approved Use

Repatha® is an injectable prescription medicine used:

  • in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of heart surgery. READ MORE
  • along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia [HeFH]) to reduce low-density lipoprotein (LDL) or bad cholesterol.

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How to 
Take 
Repatha®

Repatha® is available in three injection options. Learn more about each Repatha® dosing option below and the support available to assist you.

General FAQs  
✖Still have questions?

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Take Every Two Weeks

SureClick® Autoinjector

Single-dose prefilled autoinjector*

15-second at-home self-injection with hand-held device

or Download our Injection Overview Resource

Watch the demo video

Take Once a Month

Pushtronex® System

Single-dose on-body infusor with prefilled cartridge†

5-minute at-home self-injection with hands-free device

Watch the demo video

Prefilled Syringe§

A single-use prefilled syringe is also available.

Watch the demo video

§140 mg/mL

INJECTION 
SUPPORT

36°F - 46°F
68°F - 77°F

Storing and traveling with Repatha®

Store Repatha® in the refrigerator (36°F to 46°F) until you’re ready to use it. Repatha® can also be stored at room temperature (68°F to 77°F) in its original box for up to 30 days. This makes it easier to take your medicine with you when you’re on the go.

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Talk to a RepathaReady® Nurse*

RepathaReady® nurses are here to help. Do you have a question about Repatha® or need injection support? Call us. RepathaReady® Nurse support is available in other languages, including Spanish.

RepathaReady® nurses are available 7 days a week by phone at 1-844-REPATHA (1-844-737-2842), 8 AM–11 PM ET.
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Medication reminders

Would you like a reminder when it’s time to inject Repatha® or refill your prescription?
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Get a Needle Disposal Container

Needle-disposal containers can be mailed to your door, so you can recycle your used needles safely, conveniently, and at no cost to you.

FREQUENTLY ASKED QUESTIONS

Store Repatha® in the refrigerator (36°F to 46°F), in its original box, until you’re ready to use it.

It's best to store Repatha® in the refrigerator (36°F to 46°F), but Repatha® can be stored at room temperature (up to 77°F) for up to 30 days in its original box.

In the event of a temporary room temperature exposure (up to 77°F), Repatha® may be returned to the refrigerator (36°F to 46°F) for the duration of its shelf life.

If you left Repatha® out at room temperature for more than 30 days, discard Repatha®. If you think the room temperature went above 77°F, call 1-844-REPATHA (1-844-737-2842) to learn more.

Yes. Make sure your Repatha® is in its original box and clearly labeled. Learn more about how to store Repatha®.

Check your transportation provider's policy for needles. If flying, bring a copy of your prescription or a doctor’s note to show airport security.

If you forget to use Repatha® or if you are not able to take your regularly scheduled dose, inject your next dose as soon as you remember, as long as it is within 7 days of the late dose. If it is more than 7 days from the missed dose and you are using the autoinjector every-2-week dose, inject the next dose based on your original schedule. This will put you back on your original schedule. If it is more than 7 days from the late dose and you are using the once-monthly dose, inject the dose and start a new schedule based on this date. If you are not sure when to take Repatha® after a late dose, ask your healthcare provider or pharmacist.1

Put the used autoinjector/orange needle cap OR the Pushtronex® in an FDA-cleared sharps-disposal container right away after use. Do not throw away (dispose of) the autoinjector/orange cap OR the Pushtronex® in your household trash. If you do not have an FDA-cleared sharps-disposal container, you may use a household container that is made of a heavy-duty plastic; can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out; upright and stable during use; leak-resistant; and properly labeled to warn of hazardous waste inside the container.2

When your sharps-disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps-disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at www.fda.gov/safesharpsdisposal.2

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site. These are not all the possible side effects of Repatha®. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Ask your healthcare provider or pharmacist for more information.3

Click here for the SureClick® Autoinjector reference guide

You may use any of these approved injection sites: thigh; stomach (abdomen), except for a two-inch area around your navel (belly button); outer area of upper arm (outer arm only if someone else is giving you the injection).2

If your healthcare provider decides that you or a caregiver can give Repatha®, you or your caregiver should receive training on the right way to prepare and inject Repatha®. Do not try to inject Repatha® until you have been shown the right way by your healthcare provider or nurse. For the step-by-step injection support video, please visit us at www.repathainjection.com. Still have questions? Please call us at 1-844-REPATHA
(1-844-737-2842).

You can use your thigh; stomach (abdomen), except for a two-inch area around your navel (belly button); outer area of upper arm (outer arm only if someone else is giving you the injection). Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid injecting into areas with wrinkles, skin folds, scars, stretch marks, moles, or excessive hair. Avoid injecting directly into raised, thick, red, or scaly skin patch or lesion. It is recommended that you choose a different site each time you give yourself an injection. If you want to use the same injection site, make sure it is not the same spot you used for the last injection.2

You can do either one as long as you create a firm surface. When pinching, make sure to pinch the skin firmly between your thumb and fingers, creating an area about two inches wide. You may also stretch the skin by moving your thumb and fingers in opposite directions, creating an area about two inches wide.2

In order to inject correctly, firmly push down the autoinjector against the skin. Then press the gray start button. You will hear a click. While still pushing the autoinjector down on your skin, you can then lift your thumb off of the gray button. The injection could take about 15 seconds.

You can lift your finger (thumb) off the gray start button and place the prefilled autoinjector back on your injection site. Then, you can press the gray start button again. Ensure to push down the autoinjector firmly onto the skin, at a 90-degree angle until it stops moving. For more information, contact your healthcare provider and/or call 1-844-REPATHA (1-844-737-2842).2

The SureClick® and PFS have a needle size of 27 gauge, ½ inch in length.

Your injection could take about 15 seconds. The inspection window will start to fill with the yellow plunger once a click is heard, indicating the injection sequence has commenced. The injection will be complete once the entire window is fully yellow. You may hear a second click. When you remove the autoinjector, if the window has not turned yellow, or if it looks like there is still medicine in the window and the plunger has stopped moving, this means you have not received a full dose. Call your healthcare provider immediately for further guidance.2

Pull the orange cap straight off only when you are ready to inject. Do not leave the orange cap off for more than 5 minutes.2

Waiting longer than 5 minutes can dry out the medicine and/or clog the needle.2

The yellow safety guard with the needle inside should be in contact with the skin at a 90-degree angle.2

The injection is subcutaneous – which is very shallow, just under the skin.1

You must wait for at least 30 minutes after removing the autoinjector from the refrigerator prior to injecting yourself to ensure complete medication is administered and to minimize discomfort. Reminder: Do not remove the needle shield/cap from the autoinjector until you are ready to inject.2

No, use another clean alcohol swab.4

To securely attach the on-body infusor, prepare and clean an injection site that is less likely to have body hair, or you can trim the area. Use a firm and flat skin surface. Clean your injection site with an alcohol wipe and let your skin dry. For best results, use the device while sitting to minimize movement.4

You can use your thigh; stomach (abdomen), except for a two-inch area around your belly button; outer area of upper arm (outer arm only if someone else is giving you the injection). Do not inject into areas where the skin is tender, bruised, red or hard. Avoid injecting into areas with wrinkles, skin folds, scars, stretch marks, moles and excessive hair. It is recommended that you choose a different site each time you give yourself an injection. If you want to use the same injection site, make sure it is not the same spot you used for the last injection.4

The Pushtronex® has a needle size of 29 gauge, ¼ inch in length.

The single-use on-body infusor with prefilled cartridge is not made with natural rubber latex.3

For your injection, take your Pushtronex® and prefilled cartridge out of the refrigerator and let them sit at room temperature for at least 45 minutes before you insert the cartridge and inject. Do not let the Pushtronex® get wet from water or any other liquids. Do not try to warm the prefilled cartridge by using a heat source such as hot water or a microwave.1

If you have removed the adhesive backing and pressed the start button, the on-body infusor will make a beeping sound, and you will see the blinking red light. The on-body infusor will stop. Stop using the Pushtronex® and call 1-844-REPATHA (1-844-737-2842).4

Waiting longer than 5 minutes can dry out the medicine and/or clog the needle.4

The injection is finished when the status light changes to solid green, you will hear several beeps, and the plunger fills the medicine window all the way. It is okay to hear the pumping sound start and stop during injection. Once the Pushtronex® is removed from the skin, the green light should turn off.4

You must wait for at least 45 minutes after removing from the refrigerator prior to injecting yourself to ensure complete medication is administered and to minimize discomfort. Reminder: Do not remove the needle shield/cap from the autoinjector until you are ready to inject.2

Load the cleaned cartridge into the Pushtronex® and firmly press on the top until it is secured in place.4

Cartridge top should not be removed. If you have accidentally done so, please call 1-844-REPATHA (1-844-737-2842).4

References: 1. Repatha® (evolocumab) prescribing information, Amgen. 2. Repatha® (evolocumab) SureClick® Autoinjector instructions for use, Amgen. 3. Repatha® (evolocumab) patient product information, Amgen. 4. Repatha® (evolocumab) Pushtronex® instruction for use, Amgen.

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Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-dose prefilled syringes and the inside of the needle caps on the single-dose prefilled SureClick® autoinjectors contain dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?

Repatha® can cause serious side effects including, serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information.

Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-dose prefilled syringes and the inside of the needle caps on the single-dose prefilled SureClick® autoinjectors contain dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?

Repatha® can cause serious side effects including, serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information.

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