Approved Use

Repatha® is an injectable prescription medicine used:

  • in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of heart surgery. READ MORE
  • along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia) to reduce low-density lipoprotein (LDL) or bad cholesterol.

What Is Repatha®?

For adults with heart disease, Repatha® is a treatment that dramatically lowers LDL bad cholesterol and reduces the risk of heart attack and stroke. If you’re taking a statin, but you are still struggling to lower your LDL, it’s time for a different approach.

How Repatha® works differently than a statin

  • Repatha®

    Repatha® helps the liver clear LDL bad cholesterol by limiting the actions of a protein called PCSK9—and less PCSK9 means less LDL in your blood.

  • +

  • Statins

    Statins help stop your liver from making as much cholesterol, including LDL.

    They also increase the liver’s ability to break down cholesterol that’s already in your blood.

  • =

  • Dramatically Lower LDL

    Taken together, Repatha® with a statin is proven to dramatically lower your LDL.

Results with Repatha®

  • In adults with heart disease


    63%

    Reduction in LDL Cholesterol

    By adding Repatha® to a statin, patients are able to achieve a 63% reduction in LDL-C levels at week 12.

  • 27%

    Reduced risk of Heart Attack

    In a study, patients not treated with Repatha® had more heart attacks (4.6%) compared to those treated with Repatha® (3.4%).

    21%

    Reduced risk of Stroke

    In a study, patients not treated with Repatha® had more strokes (1.9%) compared to those treated with Repatha® (1.5%).

  • Worked within 4 weeks:

    Most people experienced their greatest drop in LDL bad cholesterol with Repatha® in as little as 4 weeks; this drop was maintained with treatment.

  • Reduces certain types of heart surgery:

    Repatha® is also proven to reduce the need for a stent or open-heart bypass surgery.

REPATHA® AND HeFH

For people with inherited high bad cholesterol (familial hypercholesterolemia or FH) who still need to lower LDL bad cholesterol along with diet alone or together with other cholesterol-lowering medicines.

For some people, diet, weight, or physical activity level might not be the primary cause of high LDL. Sometimes high LDL is caused by an inherited condition called FH.

HeFH represents one form of this common genetic disorder that affects the liver's ability to remove excess LDL. HeFH is an inherited condition, which means it is caused by one or more abnormal genes that can be passed down from one or both parents. This can lead to premature cardiovascular disease, as well as other complications caused by high LDL.

Repatha® + a statin lowered LDL around 60%*

*Results from a study at week 12 compared to a statin. Some patients were also on other cholesterol-lowering therapies. Repatha® was taken every 2 weeks or once monthly. Your results may vary.

Learn more about HeFH and Repatha®

Get the HeFH Fact Sheet

Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-use prefilled syringes and the inside of the needle caps on the single-use prefilled SureClick® autoinjectors contain dry natural rubber. The single-use Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?

Repatha® can cause serious side effects including, serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information.

Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-use prefilled syringes and the inside of the needle caps on the single-use prefilled SureClick® autoinjectors contain dry natural rubber. The single-use Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?

Repatha® can cause serious side effects including, serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information.

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