For people with inherited high bad cholesterol (HeFH) who still need to lower LDL along with diet and a maximally tolerated statin

How Repatha® can significantly lower inherited high LDL

You can inherit genes from your family that cause your LDL (bad cholesterol) to be very high.
Inherited high LDL comes from an abnormal gene. This abnormal gene affects your liver’s ability to remove LDL from your blood.

If your doctor told you that you have this condition, it’s more likely that another close family member—such as a sibling or child—will also have it.

High LDL can run in families

HeFH: A common type of inherited high LDL

Heterozygous familial hypercholesterolemia (HeFH)
(pronounced het-er-oh-zi-gus fa-mill-e-al hi-per-ko-les-ter-ol-e-me-ah)
is one of the most common genetic disorders. People with HeFH inherit
the abnormal gene from one parent.

At least
1 in 250
people worldwide
may have HeFH

More than 90% of people with HeFH do not know they have it

How HeFH may be diagnosed

Your doctor may use several different methods to diagnose HeFH.
For example, he or she may:

  • Take a blood test to measure cholesterol, including LDL
  • Ask about your family history
    • Do you have close relatives with HeFH?
    • Have any relatives had coronary heart disease at a young age?
  • Perform a physical to check for signs of HeFH
  • Suggest you have a DNA test to check for genes that cause HeFH

How to manage HeFH

You've probably been working with your doctor and already know what you need to do to manage inherited high LDL:
Eat right and get enough physical activity.

However, these lifestyle changes alone may not be enough to lower LDL for people with inherited high LDL.

In fact, most people will also need to take more than one kind of medicine, including a statin, to further lower their LDL.

Results with Repatha®

Repatha® drives down LDL in people with HeFH

Repatha® + a statin

lowered LDL around

*Results from a study at week 12 compared to a statin. Some patients were also on other cholesterol-lowering therapies. Repatha® was taken every 2 weeks or once monthly. Your results may vary.

Check out HeFH signs
& related conditions

Generally, high LDL has no symptoms, but people with HeFH could have signs of high cholesterol. Find out more


Important Safety Information and Approved Use

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including allergies, and if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-use prefilled syringes and the inside of the needle caps on the single-use prefilled SureClick® autoinjectors contain dry natural rubber. The single-use Pushtronex system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

What are the possible side effects of Repatha®?

Repatha® may cause allergic reactions. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-10881-800-FDA-1088.

Approved Use

Repatha® is an injectable prescription medicine called a PCSK9 inhibitor. Repatha® is used:

  • along with diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL) or atherosclerotic heart or blood vessel problems, who need additional lowering of LDL cholesterol.

The effect of Repatha® on heart problems, such as heart attacks, stroke, or death, has not been determined.

Please see full Prescribing Information on this website.

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