Store Repatha^® in the refrigerator (36°F to 46°F), in its original box, until you’re ready to use it.

Yes. Make sure your Repatha^® is in its original box and clearly labeled. Learn more about how to store Repatha^®.

Check your transportation provider’s policy for needles. If flying, bring a copy of your prescription or a doctor’s note to show airport security.

Repatha^® must be used within 30 days if kept at room temperature (68°F to 77°F) in its original box.

If you forget to use Repatha^® or if you are not able to take your regularly scheduled dose, inject your next dose as soon as you remember, as long as it is within 7 days of the late dose. If it is more than 7 days from the missed dose and you are using the autoinjector every-2-week dose, inject the next dose based on your original schedule. This will put you back on your original schedule. If it is more than 7 days from the late dose and you are using the once-monthly dose, inject the dose and start a new schedule based on this date. If you are not sure when to take Repatha^® after a late dose, ask your healthcare provider or pharmacist.¹

Put the used autoinjector/orange needle cap OR the Pushtronex^® in an FDA-cleared sharps-disposal container right away after use. Do not throw away (dispose of) the autoinjector/orange cap OR the Pushtronex^® in your household trash. If you do not have an FDA-cleared sharps-disposal container, you may use a household container that is made of a heavy-duty plastic; can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out; upright and stable during use; leak-resistant; and properly labeled to warn of hazardous waste inside the container.²

When your sharps-disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps-disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at www.fda.gov/safesharpsdisposal.²

It’s best to store Repatha^® in the refrigerator (36°F to 46°F), but Repatha^® can be stored at room temperature (up to 77°F) for up to 30 days in its original box.

In the event of a temporary room temperature exposure (up to 77°F), Repatha^® may be returned to the refrigerator (36°F to 46°F) for the duration of its shelf life.

If you left Repatha^® out at room temperature for more than 30 days, discard Repatha^®. If you think the room temperature went above 77^°F, call 1-844-REPATHA (1-844-737-2842) to learn more.

The most common side effects of Repatha^® include runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site. These are not all the possible side effects of Repatha^®. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Ask your healthcare provider or pharmacist for more information.³

You may use any of these approved injection sites: thigh; stomach (abdomen), except for a two-inch area around your navel (belly button); outer area of upper arm (outer arm only if someone else is giving you the injection).²
If your healthcare provider decides that you or a caregiver can give Repatha^®, you or your caregiver should receive training on the right way to prepare and inject Repatha^®. Do not try to inject Repatha^® until you have been shown the right way by your healthcare provider or nurse. For the step-by-step injection support video, please visit us at www.repathainjection.com. Still have questions? Please call us at 1-844-REPATHA (1-844-737-2842).

You can do either one as long as you create a firm surface. When pinching, make sure to pinch the skin firmly between your thumb and fingers, creating an area about two inches wide. You may also stretch the skin by moving your thumb and fingers in opposite directions, creating an area about two inches wide.²

You can lift your finger (thumb) off the gray start button and place the prefilled autoinjector back on your injection site. Then, you can press the gray start button again. Ensure to push down the autoinjector firmly onto the skin, at a 90-degree angle until it stops moving. For more information, contact your healthcare provider and/or call 1-844-REPATHA (1-844-737-2842).²

Your injection could take about 15 seconds. The inspection window will start to fill with the yellow plunger once a click is heard, indicating the injection sequence has commenced. The injection will be complete once the entire window is fully yellow. You may hear a second click. When you remove the autoinjector, if the window has not turned yellow, or if it looks like there is still medicine in the window and the plunger has stopped moving, this means you have not received a full dose. Call your healthcare provider immediately for further guidance.²

Waiting longer than 5 minutes can dry out the medicine and/or clog the needle.²

You can use your thigh; stomach (abdomen), except for a two-inch area around your navel (belly button); outer area of upper arm (outer arm only if someone else is giving you the injection). Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid injecting into areas with wrinkles, skin folds, scars, stretch marks, moles, or excessive hair. Avoid injecting directly into a raised, thick, red, or scaly skin patch or lesion. It is recommended that you choose a different site each time you give yourself an injection. If you want to use the same injection site, make sure it is not the same spot you used for the last injection.²

In order to inject correctly, firmly push the Autoinjector down against the skin. Then press the gray start button. You will hear a click. While still pushing the Autoinjector down on your skin, you can then lift your thumb off of the gray button. The injection could take about 15 seconds.

The SureClick^® and Prefilled Syringe have a needle size of 27 gauge, ½ inch in length.

Pull the orange cap straight off only when you are ready to inject. Do not leave the orange cap off for more than 5 minutes.²

The yellow safety guard with the needle inside should be in contact with the skin at a 90-degree angle.²

You should not be able to hit a vein. The injection is subcutaneous—which is very shallow, just under the skin.¹

You must wait for at least 30 minutes after removing the autoinjector from the refrigerator prior to injecting yourself to ensure all of the medication is administered and to minimize discomfort.

Reminder: Do not remove the needle shield/cap from the autoinjector until you are ready to inject.²

No, use another clean alcohol swab.⁴

You can use your thigh; stomach (abdomen), except for a two-inch area around your belly button; outer area of upper arm (outer arm only if someone else is giving you the injection). Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid injecting into areas with wrinkles, skin folds, scars, stretch marks, moles, or excessive hair. It is recommended that you choose a different site each time you give yourself an injection. If you want to use the same injection site, make sure it is not the same spot you used for the last injection.⁴

Yes. The single-dose on-body infusor with prefilled cartridge is not made with natural rubber latex.³

If you have removed the adhesive backing and pressed the start button, the on-body infusor will make a beeping sound, and you will see the blinking red light. The on-body infusor will stop. Stop using the Pushtronex^® and call 1-844-REPATHA (1-844-737-2842).⁴

The injection is finished when the status light changes to solid green, you hear several beeps, and the plunger fills the medicine window all the way. It is okay to hear the pumping sound start and stop during injection. Once the Pushtronex^® is removed from the skin, the green light should turn off.⁴

Load the cleaned cartridge into the Pushtronex^® and firmly press on the top until it is secured in place.⁴

To securely attach the on-body infusor, prepare and clean an injection site that is less likely to have body hair, or you can trim the area. Use a firm and flat skin surface. Clean your injection site with an alcohol wipe and let your skin dry. For best results, use the device while sitting to minimize movement.⁴

The Pushtronex^® has a needle size of 29 gauge, 1/4 inch in length.

For your injection, take your Pushtronex^® and prefilled cartridge out of the refrigerator and let them sit at room temperature for at least 45 minutes before you insert the cartridge and inject. Do not let the Pushtronex^® get wet from water or any other liquids. Do not try to warm the prefilled cartridge by using a heat source such as hot water or a microwave.¹

Waiting longer than 5 minutes can dry out the medicine and/or clog the needle.⁴

You must wait for at least 45 minutes after removing from the refrigerator prior to injecting yourself to ensure complete medication is administered and to minimize discomfort. Reminder: Do not remove the needle shield/cap from the autoinjector until you are ready to inject.²

The cartridge top should not be removed. If you have accidentally done so, please call 1-844-REPATHA (1-844-737-2842).⁴