Approved Use

Repatha® is an injectable prescription medicine called a PCSK9 inhibitor. Repatha® is used:

  • along with diet and maximally tolerated statin therapy in adults with Read more heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL) or atherosclerotic heart or blood vessel problems, who need additional lowering of LDL cholesterol. Read more

The effect of Repatha® on heart problems, such as heart attacks, stroke, or death, has not been determined.

Repatha® is the first and only medication of its kind to offer an every-two-week or single monthly injection option. Learn more about each Repatha® dosing option below and talk to your doctor to determine which choice is right for you.

Already taking Repatha®? Click here to watch device demonstration videos.

Every two weeks

SureClick® autoinjector

Single-use prefilled autoinjector*

15-second self-injection with hand-held device

Taken every two weeks

  • Audible click when you start and finish your dose
  • Hidden needle
  • Can inject into your stomach or thigh, or inject into your arm if assisted
  • No need for syringes or vials
Watch demonstration video

Read the full video transcript

Prior to injecting, download and review the SureClick® Autoinjector Instructions for Use.

*140 mg/mL
Injection under the skin

Once a month

Pushtronex® system

Single-use on-body infusor with prefilled cartridge

9-minute injection with hands-free device

Taken once a month

  • Lights and sounds when you start and finish your dose
  • Hidden needle
  • Can inject into your stomach or thigh, or inject into your arm if assisted
  • Can do moderate physical activities during injection
  • Fits in the palm of your hand
Watch demonstration video

Read the full video transcript

Prior to injecting, download and review the Pushtronex® System Instructions for Use.

420 mg/3.5 mL
Injection under the skin

Prefilled syringe

A single-use prefilled syringe is also available. Watch the injection demonstration video below to learn how to use it.

Watch demonstration video

Prior to injecting, download and review the prefilled syringe Instructions for Use.

Storing and traveling with Repatha®

Store Repatha® in the refrigerator (36°F to 46°F) until you’re ready to use it. Repatha® can also be kept at room temperature (68°F to 77°F) in its original box for up to 30 days. This makes it easier to take your medicine with you when you’re on the go.


Repatha® demonstration videos

Already taking Repatha®? Get an overview on how to take your medication with the SureClick® autoinjector, Pushtronex® system (on-body infusor with prefilled cartridge), or prefilled syringe.

SureClick® autoinjector

Prior to injecting, download and review the SureClick® autoinjector Instructions for Use here.

Pushtronex® system

Prior to injecting, download and review the Pushtronex® system Instructions for Use here.

Prefilled syringe

Prior to injecting, download and review the prefilled syringe Instructions for Use here.


Get nurse support now

Have questions about taking Repatha®? Call 1-844-REPATHA (1-844-737-2842) 7 days a week, 9AM – 11PM EST, to speak with a nurse or schedule an injection training.

See more services from RepathaReady®

Get free needle disposal containers

Recycle your used needles safely, conveniently, and at no cost to you with needle disposal containers that are mailed to your door.

Get needle disposal containers

Important Safety Information and Approved Use

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including allergies, and if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-use prefilled syringes and the inside of the needle caps on the single-use prefilled SureClick® autoinjectors contain dry natural rubber. The single-use Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

What are the possible side effects of Repatha®?

Repatha® may cause allergic reactions. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Approved Use

Repatha® is an injectable prescription medicine called a PCSK9 inhibitor. Repatha® is used:

The effect of Repatha® on heart problems, such as heart attacks, stroke, or death, has not been determined.

Important Safety Information and Approved Use

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including allergies, and if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-use prefilled syringes and the inside of the needle caps on the single-use prefilled SureClick® autoinjectors contain dry natural rubber. The single-use Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

What are the possible side effects of Repatha®?

Repatha® may cause allergic reactions. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Approved Use

Repatha® is an injectable prescription medicine called a PCSK9 inhibitor. Repatha® is used:

  • along with diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL) or atherosclerotic heart or blood vessel problems, who need additional lowering of LDL cholesterol.

The effect of Repatha® on heart problems, such as heart attacks, stroke, or death, has not been determined.