Approved Use

Repatha® is an injectable prescription medicine called a PCSK9 inhibitor. Repatha® is used:

  • along with diet and maximally tolerated statin therapy in adults with Read more heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL) or atherosclerotic heart or blood vessel problems, who need additional lowering of LDL cholesterol. Read more

The effect of Repatha® on heart problems, such as heart attacks, stroke, or death, has not been determined.

As you may already know, LDL cholesterol is often called bad cholesterol because it can build up in the walls of your arteries and form plaque, which can narrow and reduce the flow of blood through your arteries (arteries are the blood vessels that carry blood away from your heart). This plaque buildup can lead to a condition called atherosclerosis (ath-uh-roh-skluh-ro-sis)—also known as “the hardening of the arteries.”

High LDL cholesterol can build up and form plaque

Your doctor may diagnose you with atherosclerotic heart or blood vessel problems if you have any of the conditions or procedures discussed below

Conditions

Angina: Symptoms may include chest pressure or tightness

Heart attack: Symptoms may include pressure in the chest or discomfort in the arms, back, neck, jaw, or stomach. Shortness of breath or feeling nauseous or lightheaded may also occur

Stroke: Symptoms can include numbness or weakness in the face, arm, or leg

TIA (or mini-stroke): Stroke-like symptoms can come on quickly and last about a minute

Peripheral artery disease (PAD): Symptoms may include leg or buttocks pain during physical activity, such as walking. The pain goes away when the activity stops

Procedures

Stent: A wire mesh tube is inserted into an artery to keep it open so blood flows to the heart

Bypass surgery: Reroutes blood flow around clot to improve blood flow to the heart muscle


What causes high LDL?

Cholesterol is a type of fat found in your blood. Different factors can affect your cholesterol levels, such as diet, weight, lack of physical activity, and gender. You can also inherit the genes from your family that cause your cholesterol to be high.

High cholesterol, including LDL cholesterol, has no symptoms.

Even if you're eating right and taking a statin, your high LDL levels may still be uncontrolled.


Why it’s important to treat high LDL

Higher LDL levels can increase your risk of heart disease, in addition to an increased risk of heart attack and stroke. That’s why it’s important to stay on top of your high LDL treatment.

Eating right and taking a statin are important factors for maintaining your LDL level. What you may not know, however, is that even if you’re doing all of this, your high LDL may still be uncontrolled.

High LDL has no symptoms—only a blood test can tell if your LDL is high.

Talk to your doctor about high LDL

Get customized talking points to help have an informed conversation at your next doctor’s appointment.

Build your Doctor Discussion Guide

Need extra resources to help lower your LDL?

Get additional information to help manage your LDL treatment with these helpful online cholesterol resources.

Learn more

Important Safety Information and Approved Use

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including allergies, and if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-use prefilled syringes and the inside of the needle caps on the single-use prefilled SureClick® autoinjectors contain dry natural rubber. The single-use Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

What are the possible side effects of Repatha®?

Repatha® may cause allergic reactions. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Approved Use

Repatha® is an injectable prescription medicine called a PCSK9 inhibitor. Repatha® is used:

The effect of Repatha® on heart problems, such as heart attacks, stroke, or death, has not been determined.

Important Safety Information and Approved Use

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including allergies, and if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-use prefilled syringes and the inside of the needle caps on the single-use prefilled SureClick® autoinjectors contain dry natural rubber. The single-use Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

What are the possible side effects of Repatha®?

Repatha® may cause allergic reactions. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Approved Use

Repatha® is an injectable prescription medicine called a PCSK9 inhibitor. Repatha® is used:

  • along with diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL) or atherosclerotic heart or blood vessel problems, who need additional lowering of LDL cholesterol.

The effect of Repatha® on heart problems, such as heart attacks, stroke, or death, has not been determined.