What you may not know about LDL cholesterol

Your body needs cholesterol to help it work right.
But having too much LDL (bad cholesterol) can be a problem.

What causes high LDL

Cholesterol is a type of fat found in your blood. Different factors can affect your cholesterol levels, such as diet, weight, lack of physical activity, and gender. You can also inherit the genes from your family that cause your cholesterol to be high.

High cholesterol, including LDL cholesterol, has no symptoms.

Even if you're eating right and taking a statin, your high LDL levels may still be uncontrolled.

High LDL can build up and form plaque

LDL is called bad cholesterol because it can build up in the walls of your arteries and form plaque.

This plaque build-up can lead to a condition called hardening of arteries (also known as atherosclerosis, pronounced ath-uh-roh-skluh-ro-sis).

Normal artery Cholesterol build-up in artery (atherosclerosis)

Understanding atherosclerotic heart and blood vessel problems

Your doctor may diagnose you with atherosclerotic heart or blood vessel problems if you have any of the conditions or procedures discussed below.


Angina: Symptoms may include chest pressure or tightness

Heart attack: Symptoms may include pressure in the chest, discomfort in the arms, back, neck, jaw, or stomach. Shortness of breath or feeling nauseous or lightheaded may also occur

Stroke: Symptoms can include numbness or weakness in the face, arm, or leg

TIA (or mini-stroke): Stroke-like symptoms can come on quickly and last about a minute

Peripheral artery disease (PAD): Symptoms may include leg or buttocks pain during physical activity, such as walking. The pain goes away when the activity stops


Stent: A wire mesh tube is inserted into an artery to keep it open so blood flows to the heart

Bypass surgery: Reroutes blood flow around clot to improve blood flow to the heart muscle

If you have atherosclerotic heart or blood vessel problems and you are already taking a statin, but you still have high LDL, talk to your doctor about lifestyle changes and an additional treatment option to determine a treatment plan that’s right for you.

Finding the right treatment plan is especially important if you have inherited high LDL, called HeFH.

What are some signs of inherited high LDL (HeFH)?

Generally, high LDL has no signs or symptoms. But, if you do have HeFH you may have:

  • Very high LDL, starting at birth
  • Fatty deposits under the skin, especially around the Achilles tendon and hand tendons
  • Yellow fatty deposits on your eyelids
  • Gray, white, or blue circles around your cornea
  • Chest pain
  • Stroke-like symptoms

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Questions about
paying for Repatha®?

Pay no more than $5* with the Repatha® Copay Card, and learn about other financial programs

*Eligibility Requirements for Repatha® Copay Card: Program is available to patients with commercial insurance and applies to deductible, coinsurance, and copay for Repatha®. This program is not open to patients receiving prescription reimbursement under any federal, state or government-funded healthcare program, such as Medicare, Medicare Advantage, Medicare Part D, Medicaid, Medigap, Veterans Affairs (VA), the Department of Defense (DoD) or TRICARE® or where prohibited by law.

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Important Safety Information and Approved Use

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including allergies, and if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-use prefilled syringes and the inside of the needle caps on the single-use prefilled SureClick® autoinjectors contain dry natural rubber. The single-use Pushtronex system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

What are the possible side effects of Repatha®?

Repatha® may cause allergic reactions. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-10881-800-FDA-1088.

Approved Use

Repatha® is an injectable prescription medicine called a PCSK9 inhibitor. Repatha® is used:

  • along with diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL) or atherosclerotic heart or blood vessel problems, who need additional lowering of LDL cholesterol.

The effect of Repatha® on heart problems, such as heart attacks, stroke, or death, has not been determined.

Please see full Prescribing Information on this website.

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